Journal article icon

Journal article

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

Abstract:
Aims: Clinical markers of cardiac autonomic function, such as heart rate and response to exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required cofactor for enzymes with roles in cardiac autonomic function, including tyrosine hydroxylase and nitric oxide synthase. Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH), encoded by GCH1. Recent clinical studies report associations between GCH1 variants and increased heart rate,... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1093/cvr/cvs005

Authors


De Bono, JP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Expand authors...
British Heart Foundation More from this funder
Medical Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
31
Issue:
4
Pages:
78-78
Publication date:
2012
DOI:
EISSN:
1755-3245
ISSN:
0195-668X
URN:
uuid:f68a797a-e8ef-4f87-895b-8df9ca943e93
Source identifiers:
132198
Local pid:
pubs:132198

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP