Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
Aims: Clinical markers of cardiac autonomic function, such as heart rate and response to exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required cofactor for enzymes with roles in cardiac autonomic function, including tyrosine hydroxylase and nitric oxide synthase. Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH), encoded by GCH1. Recent clinical studies report associations between GCH1 variants and increased heart rate,... Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher copy:
- Oxford University Press Publisher's website
- Cardiovascular Research Journal website
- Publication date:
- Source identifiers:
- Local pid:
- Copyright holder:
- Adlam et al.
- Copyright date:
- Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2012.