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Journal article

X-ray crystallography of agonist/antagonist-bound receptors.

Abstract:
Crystallographic analysis of the ligand-binding domains of nuclear hormone receptors (NR) has provided a unique insight into the molecular events that underlie the ligand-mediated control of their transcriptional activity. The technique relies on preparing milligram quantities of protein, growing three-dimensional crystals of the desired protein-ligand complex, collecting X-ray diffraction data, and subsequently interpreting the derived electron density maps to reveal the structure of the complex.

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Journal:
Methods in molecular biology (Clifton, N.J.) More from this journal
Volume:
505
Pages:
51-66
Publication date:
2009-01-01
ISSN:
1064-3745
Language:
English
Subjects:
UUID:
uuid:f685ed60-af75-4814-b762-27e20824ea41
Local pid:
SGC:19117139
Deposit date:
2011-08-18

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