Journal article icon

Journal article

AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.

Abstract:
An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

Actions


Access Document


Publisher copy:
10.1038/nm1333

Authors


Expand authors...
Journal:
Nature medicine
Volume:
11
Issue:
12
Pages:
1290-1292
Publication date:
2005-12-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:f681ae5d-e5d6-494c-935e-5db0aaaaec05
Source identifiers:
67830
Local pid:
pubs:67830

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP