Commentary. A picture of Mitf in melanoma immortality.

Journal article

The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase progression and mitosis.

Authors: Goding, C

• Journal: Oncogene
• Volume: 30
• Issue: 20
• Pages: 2304-2306
• Place of publication: England
• Publication date: 2011-05-19
• DOI: 10.1038/onc.2010.641
• EISSN: 1476-5594
• ISSN: 0950-9232
• Language: English
• Keywords: Cell Cycle; Neoplastic Stem Cells; Microphthalmia-Associated Transcription Factor; Skin Neoplasms; Melanoma; Gene Expression Regulation, Neoplastic; Cell Differentiation; Cell Aging; Humans; Melanocytes