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A theoretical framework for prescribing radiotherapy dose distributions using patient-specific biological information.

Abstract:

We present a formalism for using functional imaging both to derive patient-specific radiobiological properties and consequently to prescribe optimal nonuniform radiotherapy dose distributions. The ability to quantitatively assess the response to an initial course of radiotherapy would allow the derivation of radiobiological parameters for individual patients. Both an iterative optimization and an analytical approach to this problem were investigated and illustrated by application to the linea...

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Publisher copy:
10.1118/1.2975229

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Medical physics More from this journal
Volume:
35
Issue:
10
Pages:
4599-4611
Publication date:
2008-10-01
DOI:
ISSN:
0094-2405
Language:
English
Keywords:
Pubs id:
pubs:312454
UUID:
uuid:f676e6bd-847b-49c2-bee6-219100dc4eca
Local pid:
pubs:312454
Source identifiers:
312454
Deposit date:
2013-11-16

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