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Characterization and localization of lipocortin 1-binding sites on rat anterior pituitary cells by fluorescence-activated cell analysis/sorting and electron microscopy.

Abstract:

Lipocortin 1 (LC1) is an important mediator of glucocorticoid action in the anterior pituitary gland, where it appears to act via cell surface binding sites to suppress peptide release. We have exploited a combination of fluorescence-activated cell (FAC) analysis/sorting and electron microscopy to detect, characterize, and localize LC1-binding sites on the surface of dispersed rat anterior pituitary cells, using human recombinant LC1 (hu-r-LC1) as a probe. High affinity (Kd = 14 +/- 3 nM) hu-...

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Publication status:
Published

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Publisher copy:
10.1210/en.138.12.5341

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Endocrinology More from this journal
Volume:
138
Issue:
12
Pages:
5341-5351
Publication date:
1997-12-01
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
Language:
English
Keywords:
Pubs id:
pubs:115260
UUID:
uuid:f67497bd-2d91-46ad-b22c-08183262a88a
Local pid:
pubs:115260
Source identifiers:
115260
Deposit date:
2012-12-19

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