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A multidrug ABC transporter with a taste for salt.

Abstract:

BACKGROUND: LmrA is a multidrug ATP-binding cassette (ABC) transporter from Lactococcus lactis with no known physiological substrate, which can transport a wide range of chemotherapeutic agents and toxins from the cell. The protein can functionally replace the human homologue ABCB1 (also termed multidrug resistance P-glycoprotein MDR1) in lung fibroblast cells. Even though LmrA mediates ATP-dependent transport, it can use the proton-motive force to transport substrates, such as ethidium bromi...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0006137

Authors


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Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Royal Society More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
7
Pages:
e6137
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:f673e99c-58a6-43fb-838c-583f7531f11b
Source identifiers:
59329
Local pid:
pubs:59329

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