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Imaging the effects of castration on bone turnover and hormone-independent prostate cancer colonization of bone.

Abstract:

INTRODUCTION: Tumor populations may selectively colonize bone that is being actively remodeled. In prostate cancer patients, androgen deprivation directly inhibits tumor growth initially, whilst induced bone loss may facilitate tumor colonization of bone by androgen-insensitive cells. We have tested this hypothesis using a xenograft model of early growth of prostate cancer in bone. METHODS: PC3 cells transfected with Green fluorescent protein (GFP) were injected into castrated and non-castrat...

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Publication status:
Published

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Publisher copy:
10.1002/pros.20833

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Journal:
The Prostate
Volume:
68
Issue:
15
Pages:
1707-1714
Publication date:
2008-11-05
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
URN:
uuid:f66e7bbb-42be-4400-a756-b0dbc203d28a
Source identifiers:
120724
Local pid:
pubs:120724

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