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The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.

Abstract:

CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a "don't-eat-me" signal. Here, we discuss recent structural analysis of CD47-SIRPα interactions and implications of this for ...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Annual Reviews Inc.
Journal:
Annual review of immunology More from this journal
Volume:
32
Issue:
1
Pages:
25-50
Publication date:
2014-01-01
DOI:
EISSN:
1545-3278
ISSN:
0732-0582
Language:
English
Keywords:
Pubs id:
pubs:438963
UUID:
uuid:f6694d28-ba92-4574-ba60-7ca635131f77
Local pid:
pubs:438963
Source identifiers:
438963
Deposit date:
2013-12-12

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