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Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.

Abstract:
The sympathetic control over excitation-contraction coupling (ECC) is mediated by the cAMP/PKA signalling pathway. However, in the myocyte, the same signalling pathway is responsible for triggering a plethora of diverse intracellular functions the control of which must be independent of the regulation of ECC. Here we discuss what are the molecular mechanisms leading to selective modulation of ECC in cardiac myocytes with a particular focus on the role of spatial confinement of PKA subsets and the compartmentalization of cAMP.

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Publisher copy:
10.1007/s10974-006-9077-2

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Journal:
Journal of muscle research and cell motility
Volume:
27
Issue:
5-7
Pages:
399-403
Publication date:
2006-01-01
DOI:
EISSN:
1573-2657
ISSN:
0142-4319
URN:
uuid:f65ca9d7-60b5-42b4-a1c5-b8539cacd66b
Source identifiers:
237749
Local pid:
pubs:237749

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