Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.

Journal article

Abstract:: The sympathetic control over excitation-contraction coupling (ECC) is mediated by the cAMP/PKA signalling pathway. However, in the myocyte, the same signalling pathway is responsible for triggering a plethora of diverse intracellular functions the control of which must be independent of the regulation of ECC. Here we discuss what are the molecular mechanisms leading to selective modulation of ECC in cardiac myocytes with a particular focus on the role of spatial confinement of PKA subsets and the compartmentalization of cAMP.

Journal:: Journal of muscle research and cell motility More from this journal
Volume:: 27
Issue:: 5-7
Pages:: 399-403
Publication date:: 2006-01-01
DOI:: 10.1007/s10974-006-9077-2
EISSN:: 1573-2657
ISSN:: 0142-4319

Language:: English
Keywords:: Protein Kinases

Cyclic AMP

Humans

Heart

Animals

Signal Transduction

Adaptor Proteins, Signal Transducing

Muscle Cells

Myocardial Contraction

Cell Compartmentation
Pubs id:: pubs:237749
UUID:: uuid:f65ca9d7-60b5-42b4-a1c5-b8539cacd66b
Local pid:: pubs:237749
Source identifiers:: 237749
Deposit date:: 2013-11-16
ARK identifier:: ark:/29072/ora_f65ca9d760b542b4a1c5b8539cacd66b

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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