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Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

Abstract:

Most cell-surface receptors for cytokines and growth factors signal as dimers, but it is unclear whether remodeling receptor dimer topology is a viable strategy to “tune” signaling output. We utilized diabodies (DA) as surrogate ligands in a prototypical dimeric receptor-ligand system, the cytokine Erythropoietin (EPO) and its receptor (EpoR), to dimerize EpoR ectodomains in non-native architectures. Diabody-induced signaling amplitudes varied from full to minimal agonism, and structures o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2015.02.011

Authors


Contributors

Garcia, K
Journal:
Cell More from this journal
Volume:
160
Issue:
6
Pages:
1196-1208
Publication date:
2015-03-01
DOI:
ISSN:
0092-8674
Language:
English
UUID:
uuid:f65a4e78-6aba-47de-a0e0-003c35819aaf
Local pid:
ora:10667
Deposit date:
2015-03-20

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