Journal article
Polymorphisms of transporter associated with antigen presentation, tumor necrosis factor-α and interleukin-10 and their implications for protection and susceptibility to severe forms of dengue fever in patients in Sri Lanka
- Abstract:
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Context: To date, a clear understanding of dengue disease pathogenesis remains elusive. Some infected individuals display no symptoms while others develop severe life-threatening forms of the disease. It is widely believed that host genetic factors influence dengue severity.
Aims: This study evaluates the relationship between certain polymorphisms and dengue severity in Sri Lankan patients.
Settings and Design: Polymorphism studies are carried out on genes for; transporter associated with antigen presentation (TAP), promoter of tumor necrosis factor-α (TNF-α), and promoter of interleukin-10 (IL-10). In other populations, TAP1 (333), TAP2 (379), TNF-α (−308), and IL-10 (−1082, −819, −592) have been associated with dengue and a number of different diseases. Data have not been collected previously for these polymorphisms for dengue patients in Sri Lanka.
Materials and Methods: The polymorphisms were typed by amplification refractory mutation system polymerase chain reaction in 107 dengue hemorrhagic fever (DHF) patients together with 62 healthy controls.
Statistical Analysis Used: Pearson's Chi-square contingency table analysis with Yates′ correction.
Results: Neither the TAP nor the IL-10 polymorphisms considered individually can define dengue disease outcome with regard to severity. However, the genotype combination, IL-10 (−592/−819/−1082) CCA/ATA was significantly associated with development of severe dengue in these patients, suggesting a risk factor to developing DHF. Also, identified is the genotype combination IL-10 (−592/−819/−1082) ATA/ATG which suggested a possibility for protection from DHF. The TNF-α (−308) GG genotype was also significantly associated with severe dengue, suggesting a significant risk factor.
Conclusions: The results reported here are specific to the Sri Lankan population. Comparisons with previous reports imply that data may vary from population to population.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 831.2KB, Terms of use)
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- Publisher copy:
- 10.4103/0974-777x.170501
Authors
- Publisher:
- Medknow Publications
- Journal:
- Journal of Global Infectious Diseases More from this journal
- Volume:
- 7
- Issue:
- 4
- Pages:
- 157-164
- Publication date:
- 2015-10-01
- DOI:
- EISSN:
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0974-8245
- ISSN:
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0974-777X
- Language:
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English
- Keywords:
- Pubs id:
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pubs:588679
- UUID:
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uuid:f65461d5-fc1b-4262-830f-92624f4171fc
- Local pid:
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pubs:588679
- Source identifiers:
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588679
- Deposit date:
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2016-03-30
- ARK identifier:
Terms of use
- Copyright holder:
- Journal of Global Infectious Diseases
- Copyright date:
- 2015
- Rights statement:
- © 2015 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
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