- Abstract:
-
Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine pathway) as well as severe noradrenaline depletions. However, lesion of the dorsal or ventral noradrenergic pathways resulted in similar noradrenaline depletions but with no eff...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0006-8993(75)90834-3
-
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- Journal:
- Brain research
- Volume:
- 83
- Issue:
- 3
- Pages:
- 419-436
- Publication date:
- 1975-01-05
- DOI:
- EISSN:
-
1872-6240
- ISSN:
-
0006-8993
- URN:
-
uuid:f6532c01-0691-40fe-a48c-aa6b34481b4e
- Source identifiers:
-
6259
- Local pid:
- pubs:6259
- Language:
- English
- Keywords:
- Copyright date:
- 1975
Journal article
The pharmacological and anatomical substrates of the amphetamine response in the rat.
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