Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine pathway) as well as severe noradrenaline depletions. However, lesion of the dorsal or ventral noradrenergic pathways resulted in similar noradrenaline depletions but with no eff...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
The pharmacological and anatomical substrates of the amphetamine response in the rat.
If you are the owner of this record, you can report an update to it here: Report update to this record