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The pharmacological and anatomical substrates of the amphetamine response in the rat.

Abstract:

Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine pathway) as well as severe noradrenaline depletions. However, lesion of the dorsal or ventral noradrenergic pathways resulted in similar noradrenaline depletions but with no eff...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Brain research
Volume:
83
Issue:
3
Pages:
419-436
Publication date:
1975-01-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:f6532c01-0691-40fe-a48c-aa6b34481b4e
Source identifiers:
6259
Local pid:
pubs:6259

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