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GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.

Abstract:

Members of the GATA-4, -5, and -6 subfamily of transcription factors are co-expressed with the homeoprotein Nkx 2.5 in the precardiac mesoderm during the earliest stages of its specification and are known to be important determinants of cardiac gene expression. Ample evidence suggests that GATA factors and Nkx 2.5 cross-regulate each other's expression; however, the temporal order of the expression of these transcription factors in vivo remains unresolved, and thus precise definition of the r...

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Publisher copy:
10.1089/scd.2005.14.425

Authors


Brewer, AC More by this author
Alexandrovich, A More by this author
Mjaatvedt, CH More by this author
Patient, RK More by this author
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Journal:
Stem cells and development
Volume:
14
Issue:
4
Pages:
425-439
Publication date:
2005-08-05
DOI:
EISSN:
1557-8534
ISSN:
1547-3287
URN:
uuid:f64615e6-7230-4768-be1a-e8db16710d4b
Source identifiers:
106933
Local pid:
pubs:106933

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