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Potential and limitations of a gamma 34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS.

Abstract:

Direct injection of viral vectors into the central nervous system has become a valuable technique for exploring the function of neurological systems and is a potential therapy for neural disease. To this end a number of herpes simplex virus (HSV)-derived vectors are currently being developed for the introduction of foreign DNA into the brain. In this study a non-neurovirulent HSV 17+ mutant, variant 1716, deleted in the gamma 34.5 gene and expressing the marker gene lacZ under the control of ...

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Publisher copy:
10.1038/sj.gt.3300639

Authors


Publisher:
Nature Publishing Group
Journal:
Gene therapy More from this journal
Volume:
5
Issue:
5
Pages:
594-604
Publication date:
1998-05-01
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
Language:
English
Keywords:
Pubs id:
pubs:113471
UUID:
uuid:f6453009-1253-4484-894d-564235fff855
Local pid:
pubs:113471
Source identifiers:
113471
Deposit date:
2013-11-17

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