Journal article icon

Journal article

Alpha-thalassaemia caused by a polyadenylation signal mutation.

Abstract:

Most eukaryotic messenger RNAs have the sequence AAUAAA 11-30 nucleotides from the 3'-terminal poly(A) tract. Since this is the only significant sequence homology in the 3' non-coding region it has been suggested that it may be a recognition site for enzymes involved in polyadenylation and/or termination of polymerase II transcription. This idea is strengthened by observations on the effect of deletion mutations in or around the AATAAA sequence on polyadenylation of late simian virus 40 (SV40...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/306398a0

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Nature More from this journal
Volume:
306
Issue:
5941
Pages:
398-400
Publication date:
1983-01-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
Pubs id:
pubs:15689
UUID:
uuid:f642af72-4ec8-4813-8807-a92e004fb72f
Local pid:
pubs:15689
Source identifiers:
15689
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP