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Journal article

Regulation of autophagy by ATF4 in response to severe hypoxia.

Abstract:

Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small interfering RNA (siRNA) and microarray analysis to provide the first whole-genome analysis of genes regulated by ATF4 in cancer cells in response to severe and prolonged hypoxic stres...

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Publication status:
Published

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Publisher copy:
10.1038/onc.2010.191

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Oncogene More from this journal
Volume:
29
Issue:
31
Pages:
4424-4435
Publication date:
2010-08-01
DOI:
EISSN:
1476-5594
ISSN:
0950-9232

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