Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses.

Journal article

Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels controls a disparate array of key cellular responses. In this review, recent work will be described that shows local Ca(2+) influx through CRAC channels has important spatial and temporal consequences on cell function. A localized Ca(2+) rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracrine pro-inflammatory molecule LTC(4). In addition, local Ca(2+) entry can activate gene expression, which develops over tens of minutes. Local Ca(2+) influx through CRAC channels therefore has far-reaching consequences on intra- and intercellular communication.

Authors: Parekh, A

• Publication status: Published
• Journal: Acta physiologica (Oxford, England)
• Volume: 195
• Issue: 1
• Pages: 29-35
• Publication date: 2009-01-01
• DOI: 10.1111/j.1748-1716.2008.01919.x
• EISSN: 1748-1716
• ISSN: 1748-1708
• Language: English
• Keywords: Time Factors; Animals; Cell Membrane; Calcium Channels; Mast Cells; Calcium