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Journal article

Local Ca2+ influx through CRAC channels activates temporally and spatially distinct cellular responses.

Abstract:

Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels controls a disparate array of key cellular responses. In this review, recent work will be described that shows local Ca(2+) influx through CRAC channels has important spatial and temporal consequences on cell function. A localized Ca(2+) rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracri...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Acta physiologica (Oxford, England) More from this journal
Volume:
195
Issue:
1
Pages:
29-35
Publication date:
2009-01-01
DOI:
EISSN:
1748-1716
ISSN:
1748-1708
Language:
English
Keywords:
Pubs id:
pubs:106223
UUID:
uuid:f62fb5c3-7c10-4fd6-88de-5fa8e65fa4b9
Local pid:
pubs:106223
Source identifiers:
106223
Deposit date:
2012-12-19

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