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FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.

Abstract:

The Fbxw7 (F-box/WD repeat-containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts as a tumor suppressor in several tissues and targets multiple transcriptional activators and protooncogenes for ubiquitin-mediated degradation. To understand Fbxw7 function in the murine intestine, in this study, we specifically deleted Fbxw7 in the murine gut using Villin-Cre (Fbxw7(ΔG)). In wild-type mice, loss of Fbxw7 in...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20100830

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Journal:
Journal of experimental medicine More from this journal
Volume:
208
Issue:
2
Pages:
295-312
Publication date:
2011-02-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007

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