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Dam inactivation in Neisseria meningitidis: prevalence among diverse hyperinvasive lineages

Abstract:

Background: DNA adenine methyltransferase (Dam) activity is absent in many, but not all, disease isolates of Neisseria meningitidis, as a consequence of the insertion of a restriction endonucleaseencoding gene, the 'dam replacing gene' (drg) at the dam locus. Here, we report the results of a survey to assess the prevalence of drg in a globally representative panel of disease-associated meningococci. Results: Of the known meningococcal hyper-invasive lineages investigated, drg was absent in al...

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Authors


Contributors

Jolley, Keith A
Sun, Li
Moxon, E Richard
Maiden, Martin C J
Publisher:
BioMed Central
Journal:
BMC Microbiology More from this journal
Issue:
4
Publication date:
2004-01-01
Subjects:
UUID:
uuid:f6285d42-eec3-4122-8a86-b579ca2c8f83
Local pid:
ora:735
Source identifiers:
http://sers009b.sers.ox.ac.uk/archive/00000777/
Deposit date:
2012-11-15

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