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Journal article

Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer.

Abstract:

PURPOSE: Anemia is considered a major factor that counteracts the efficacy of radiotherapy, presumably because of reduced oxygen availability that leads to tumor hypoxia. Nevertheless, anemia is not the only factor defining oxygen availability, because a poor and/or immature vascular network may prevent blood flow and tumor oxygenation. Furthermore, the ability of tumors to upregulate hypoxia-regulated molecular pathways may affect radiosensitivity by mechanisms independent of the traditiona...

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Publication status:
Published

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Journal:
International journal of radiation oncology, biology, physics
Volume:
59
Issue:
1
Pages:
67-71
Publication date:
2004-05-01
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Source identifiers:
119142

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