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Mefloquine antimalarial prophylaxis in pregnancy: dose finding and pharmacokinetic study.

Abstract:

1. A dose finding pharmacokinetic study was performed in 20 Karen women in the third trimester of pregnancy receiving antimalarial prophylaxis with mefloquine. Ten received 250 mg mefloquine base weekly and ten received identical tablets of 125 mg base/week. 2. Both dose regimens were well tolerated. Malaria was prevented effectively, there were no serious adverse effects, all pregnancies proceeded normally, and there were no abnormalities in the babies followed up to 2 years. 3. The median t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
British journal of clinical pharmacology
Volume:
30
Issue:
1
Pages:
79-85
Publication date:
1990-07-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:f6182e4c-63bf-4148-ab3a-cb1d1adb9732
Source identifiers:
12193
Local pid:
pubs:12193

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