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An amphioxus netrin gene is expressed in midline structures during embryonic and larval development.

Abstract:

Members of the netrin gene family have been identified in vertebrates, Drosophila and Caenorhabditis elegans and found to encode secreted molecules involved in axon guidance. Here I use the conserved function of netrins in triploblasts, coupled with the phylogenetic position of amphioxus (the closest living relative of the vertebrates), to investigate the evolution of an axon guidance cue in chordates. A single amphioxus netrin gene was isolated by PCR and cDNA library screening and named Amp...

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Publication status:
Published

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Publisher copy:
10.1007/s004270000073

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Journal:
Development genes and evolution More from this journal
Volume:
210
Issue:
7
Pages:
337-344
Publication date:
2000-07-01
DOI:
EISSN:
1432-041X
ISSN:
0949-944X

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