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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

Abstract:
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
Publication status:
Published

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Publisher copy:
10.1038/ng2058

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Journal:
Nature genetics More from this journal
Volume:
39
Issue:
7
Pages:
827-829
Publication date:
2007-07-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Keywords:
Pubs id:
pubs:111978
UUID:
uuid:f6106d97-4cc8-4289-a12a-b7e95bc3731a
Local pid:
pubs:111978
Source identifiers:
111978
Deposit date:
2012-12-19

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