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Myelin water imaging reflects clinical variability in multiple sclerosis

Abstract:

Whilst MRI is routinely used for the assessment and diagnosis of multiple sclerosis, there is poor correspondence between clinical disability in primary progressive multiple sclerosis (PPMS) patients and conventional MRI markers of disease activity (e.g., number of enhancing lesions). As PPMS patients show diffuse and global myelin loss, the aim of this study was to evaluate the efficacy of whole-brain myelin water fraction (MWF) imaging in PPMS. Specifically, we sought to use full-brain anal...

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Authors


Matthews, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Williams, SCR More by this author
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Journal:
NeuroImage
Volume:
60
Issue:
1
Pages:
263-270
Publication date:
2012-03-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:f5ff4072-affa-4695-9a6c-e302622e8704
Source identifiers:
343221
Local pid:
pubs:343221

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