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Mutations in the p53 gene are not limited to classic 'hot spots' and are not predictive of p53 protein expression in high-grade non-Hodgkin's lymphoma.

Abstract:

We have investigated the relationship between the p53 genotype and phenotype in a series of 22 high-grade non-Hodgkin's lymphomas (NHLs) in which we sequenced the p53 gene open reading frame (exons 2-11). Immunostaining for p53 was already available for these cases. Mutations were found in 10/22 cases (45%) and 3/10 were in exons 4 or 10 outside the classic 'hot spot' regions (exons 5-8). Comparison with immunostaining indicated that, besides cases with the 'expected' patterns (in which gene ...

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Publication status:
Published

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Authors


Kocialkowski, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
Morrison, H More by this author
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Journal:
British journal of haematology
Volume:
89
Issue:
1
Pages:
55-60
Publication date:
1995-01-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:f5f879d4-5405-42bc-9918-262b0dcce9bd
Source identifiers:
486726
Local pid:
pubs:486726

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