Journal article icon

Journal article

Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy.

Abstract:

BACKGROUND: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. METHODS AND FINDINGS: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 parti...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0029849

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Expand authors...
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), UK More from this funder
National Health and Medical Research Council Clinical Trials Centre (CTC), Australia More from this funder
Medical Research Council More from this funder
British Heart Foundation More from this funder
Cancer Research UK More from this funder
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
7
Issue:
1
Pages:
Article: e29849
Publication date:
2012
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:f5f58e2a-2ee6-43cf-a422-6e4000d888a1
Source identifiers:
313034
Local pid:
pubs:313034

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP