- Abstract:
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BACKGROUND: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. METHODS AND FINDINGS: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 parti...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
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(pdf, 551.8kb)
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- Publisher copy:
- 10.1371/journal.pone.0029849
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS One Journal website
- Volume:
- 7
- Issue:
- 1
- Pages:
- Article: e29849
- Publication date:
- 2012
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- URN:
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uuid:f5f58e2a-2ee6-43cf-a422-6e4000d888a1
- Source identifiers:
-
313034
- Local pid:
- pubs:313034
- Copyright holder:
- CTT Collaboration et al.
- Copyright date:
- 2012
- Notes:
- Copyright 2012 CTT Collaboration et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy.
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Funding
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), UK
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National Health and Medical Research Council Clinical Trials Centre (CTC), Australia
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Medical Research Council
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British Heart Foundation
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Cancer Research UK
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