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Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy.

Abstract:

BACKGROUND: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. METHODS AND FINDINGS: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 parti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0029849

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More from this funder
Name:
BHF Centre of Research Excellence, Oxford
More from this funder
Name:
National Heart Foundation, Australia
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Name:
Australian National Health and Medical Research Council
More from this funder
Name:
European Community Biomed Programme
Publisher:
Public Library of Science
Journal:
PloS One More from this journal
Volume:
7
Issue:
1
Article number:
e29849
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
Pubs id:
pubs:313034
UUID:
uuid:f5f58e2a-2ee6-43cf-a422-6e4000d888a1
Local pid:
pubs:313034
Source identifiers:
313034
Deposit date:
2012-12-19

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