The chirality of DNA: elasticity cross-terms at base-pair level including A-tracts and the influence of ionic strength.
A systematic analysis of B-DNA elasticity cross-terms was performed using molecular dynamics simulations of three different duplexes designed to contain all dinucleotide steps including a 6-mer A-tract. The influence of ionic strength was also evaluated by several trajectories of each molecule with different NaCl concentrations at physiological rank. Simulations show DNA flexibility is independent of salt, in agreement with the Odijk-Skolnick-Fixman model. In addition, our results demonstrate...Expand abstract
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