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Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi.

Abstract:

Borrelia burgdorferi, a spirochaete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease, the most frequent vector-borne disease in Eurasia and North America. Sporadically Lyme disease develops into a chronic, multisystemic disorder. Serum-resistant B. burgdorferi strains bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochaete surface. This binding is dependent on the expression of proteins termed complement-regulato...

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Publication status:
Published

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Publisher copy:
10.1016/j.ijmm.2006.01.011

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Volume:
296 Suppl 40
Issue:
SUPPL. 1
Pages:
177-184
Publication date:
2006-05-05
DOI:
EISSN:
1618-0607
ISSN:
1438-4221
URN:
uuid:f5e73abb-cfb0-44fc-9729-a096b68faa63
Source identifiers:
19123
Local pid:
pubs:19123

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