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Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter.

Abstract:

The production and growth regulatory activity of transforming growth factor beta were studied in human thyroid tissue. As estimated by its mRNA expression in fresh tissue samples, transforming growth factor beta was produced in normal and in diseased thyroid glands. Transforming growth factor beta mRNA was mainly produced by thyroid follicular cells and in lesser quantities by thyroid infiltrating mononuclear cells. The concentrations of transforming growth factor beta mRNA were lower in iodi...

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Publication status:
Published

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Publisher copy:
10.1172/jci113955

Authors


Grubeck-Loebenstein, B More by this author
Sadeghi, R More by this author
Kissonerghis, M More by this author
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Journal:
The Journal of clinical investigation
Volume:
83
Issue:
3
Pages:
764-770
Publication date:
1989-03-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:f5e54487-9f1d-42f9-a513-828261385eb8
Source identifiers:
481806
Local pid:
pubs:481806

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