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A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

Abstract:

Multiple sclerosis is a chronic inflammatory neurological condition characterized by focal and diffuse neurodegeneration and demyelination throughout the central nervous system. Factors influencing the progression of pathology are poorly understood. One hypothesis is that anatomical connectivity influences the spread of neurodegeneration. This predicts that measures of neurodegeneration will correlate most strongly between interconnected structures. However, such patterns have been difficu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/brain/aws242

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Institution:
University of Oxford
Department:
Harvard Medical School,Massachusetts General Hospital - Athinoula A. Martinos Centre for Biomedical Imaging
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Neurology
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Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
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Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
135
Issue:
10
Pages:
2938-2951
Publication date:
2012-10-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:f5e4a769-a592-4734-a4eb-6aefd85338eb
Local pid:
ora:7788

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