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Journal article

Cardiac magnetic resonance spectroscopy.

Abstract:
This review describes recent advances in cardiac magnetic resonance spectroscopy (MRS). MRS allows noninvasive characterization of the metabolic state of cardiac muscle, in both animal and human models. Recent experimental MRS studies have allowed new insights into the essential role of energetics in heart failure. Various new studies suggest a rapidly growing role of MRS for phenotyping new genetically modified mouse models, and recent methodologic advances include development of absolute quantification of high-energy phosphates, measurement of ATP turnover rates and thermodynamic parameters (such as free ADP and free energy change of ATP hydrolysis), and improved acquisition sequences. New patient studies demonstrate the potential value of MRS as a clinical diagnostic tool in patients with ischemic heart disease, heart failure, cardiac transplantation, valve disease, and genetic cardiomyopathy.

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Publisher copy:
10.1007/s11886-003-0041-0

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author


Journal:
Current cardiology reports More from this journal
Volume:
5
Issue:
1
Pages:
75-82
Publication date:
2003-01-01
DOI:
EISSN:
1534-3170
ISSN:
1523-3782


Language:
English
Keywords:
Pubs id:
pubs:124798
UUID:
uuid:f5dc6421-3688-4e55-8f2a-8a469735870a
Local pid:
pubs:124798
Source identifiers:
124798
Deposit date:
2012-12-19
ARK identifier:

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