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Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides.

Abstract:

Circulating angiotensin-1-converting enzyme (ACE) is a highly heritable trait, and a major component of the genetic variance maps to the region of the ACE gene. The strong effect of the locus, and the interest in ACE as a candidate gene for cardiovascular disorders, has led to extensive investigation of its relationship to the ACE phenotype, providing one of the most complete examples of quantitative trait locus (QTL) analysis in humans. Resequencing of ACE followed by haplotype analysis in f...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/11.23.2969

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Journal:
Human molecular genetics More from this journal
Volume:
11
Issue:
23
Pages:
2969-2977
Publication date:
2002-11-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906

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