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Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.

Abstract:

Zorro-LNA (Zorro) is a newly developed, oligonucleotide (ON)-based, Z-shaped construct with the potential of specific binding to each strand of duplex DNA. The first-generation Zorros are formed by two hybridized LNA/DNA mixmers (2-ON Zorros) and was hypothesized to strand invade. We have now established a method, which conclusively demonstrates that an LNA ON can strand invade into duplex DNA. To make Zorros smaller in size and easier to design, we synthesized 3'-5'-5'-3' single-stranded Zor...

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Publisher copy:
10.1093/nar/gkq835

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Journal:
Nucleic acids research
Volume:
39
Issue:
3
Pages:
1142-1154
Publication date:
2011-02-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:f5cd0c3c-66df-4997-988d-69e89e1ced56
Source identifiers:
267398
Local pid:
pubs:267398

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