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Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

Abstract:

Co-receptors add complexity to cell-cell signaling systems. The secreted semaphorin 3s (Sema3s) require a co-receptor, neuropilin (Nrp), to signal through plexin As (PlxnAs) in functions ranging from axon guidance to bone homeostasis, but the role of the co-receptor is obscure. Here we present the low-resolution crystal structure of a mouse semaphorin-plexin-Nrp complex alongside unliganded component structures. Dimeric semaphorin, two copies of plexin and two copies of Nrp are arranged as a ...

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Publisher copy:
10.1038/nsmb.2416

Authors


Janssen, BJC More by this author
Janssen, BJC More by this author
Malinauskas, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
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Journal:
Nature Structural and Molecular Biology
Volume:
19
Issue:
12
Pages:
1293-1299
Publication date:
2012-12-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:f5ca76e8-9e36-4832-b31c-1f7d14533bfb
Source identifiers:
368132
Local pid:
pubs:368132

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