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Journal article

Programmed gene rearrangements altering gene expression.

Abstract:

Programmed gene rearrangements are used in nature to to alter gene copy number (gene amplification and deletion), to create diversity by reassorting gene segments (as in the formation of mammalian immunoglobulin genes), or to control the expression of a set of genes that code for the same function (such as surface antigens). Two major mechanisms for expression control are DNA inversion and DNA transposition. In DNA inversion a DNA segment flips around and is rejoined by site-specific recombin...

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Publication status:
Published

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Publisher copy:
10.1126/science.3544215

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
Journal:
Science (New York, N.Y.)
Volume:
235
Issue:
4789
Pages:
658-667
Publication date:
1987-02-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:f5ade58f-88ce-4a31-a7d3-6cfa7a29104e
Source identifiers:
18280
Local pid:
pubs:18280

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