Journal article icon

Journal article

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.

Abstract:

The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabilization, hypoxia sensing, and translational regulation. The hypoxia-inducible factor (HIF) sensing system is conserved in animals, but not in other organisms. However, bioinformatics imply that 2OG-dependent prolyl-hydroxylases (PHDs) homologous to those acting as sensing components for the HIF system in animals occur in prokaryotes. We report cellular, biochemical, and crystallographic analys...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.1409916111

Authors


Expand authors...
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
111
Issue:
37
Pages:
13331-13336
Publication date:
2014-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f5ad67f4-4b61-430c-991e-c8f5d53a311d
Source identifiers:
484790
Local pid:
pubs:484790
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP