- Abstract:
-
The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabilization, hypoxia sensing, and translational regulation. The hypoxia-inducible factor (HIF) sensing system is conserved in animals, but not in other organisms. However, bioinformatics imply that 2OG-dependent prolyl-hydroxylases (PHDs) homologous to those acting as sensing components for the HIF system in animals occur in prokaryotes. We report cellular, biochemical, and crystallographic analys...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1409916111
-
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- Publisher:
- National Academy of Sciences
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 111
- Issue:
- 37
- Pages:
- 13331-13336
- Publication date:
- 2014-09-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:f5ad67f4-4b61-430c-991e-c8f5d53a311d
- Source identifiers:
-
484790
- Local pid:
- pubs:484790
- Language:
- English
- Copyright date:
- 2014
Journal article
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
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