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Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction

Abstract:

A single HIV-1 variant establishes infection of the host after sexual contact. Identifying the phenotypic characteristics of these Transmitted Founder (T/F) viruses is important to understand the restriction mechanisms during transmission. Langerhans cells (LCs) are the mucosal dendritic cell subset that has been shown to have a protective role in HIV-1 transmission. Immature LCs efficiently capture and degrade HIV-1 via langerin-mediated restriction. Here we have investigated the capacity of...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0226651

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-3877-9780
Publisher:
Public Library of Science
Journal:
PLoS One More from this journal
Volume:
14
Issue:
12
Article number:
e0226651
Publication date:
2019-12-19
Acceptance date:
2019-12-04
DOI:
ISSN:
1932-6203
Pubs id:
pubs:1076761
UUID:
uuid:f59bad11-4cc2-47f7-adfe-eb9e0ee1ce94
Local pid:
pubs:1076761
Source identifiers:
1076761
Deposit date:
2019-12-06

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