Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors.

Journal article

Although successful in utero hematopoietic cell transplantation (IUHCT) of X-linked severe combined immune deficiency (X-SCID) with enriched stem and progenitor cells was achieved more than a decade ago, it remains applied only in rare cases. Although this in part reflects that postnatal transplantations have overall given good results, there are no direct comparisons between IUHCT and postnatal transplantations of X-SCID. The proposed tolerance of the fetal immune system to foreign human leu...

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Authors: Liuba, K; Pronk, C; Stott, SR; Jacobsen, SE

• Publication status: Published
• Journal: Blood
• Volume: 113
• Issue: 19
• Pages: 4790-4798
• Publication date: 2009-05-01
• DOI: 10.1182/blood-2007-12-129056
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Gene Rearrangement; Mice, SCID; Lymphopoiesis; Female; Thymus Gland; Mice, Inbred C57BL; Multipotent Stem Cells; X-Linked Combined Immunodeficiency Diseases; Uterus; Bone Marrow; Animals; Hematopoietic Stem Cells; Stem Cells; Animals, Newborn; Lymphoid Progenitor Cells; Fetus; Mice; Myeloid Cells; T-Lymphocytes