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Pretreatment CD4 cell slope and progression to AIDS or death in HIV-infected patients initiating antiretroviral therapy--the CASCADE collaboration: a collaboration of 23 cohort studies.

Abstract:

BACKGROUND: CD4 cell count is a strong predictor of the subsequent risk of AIDS or death in HIV-infected patients initiating combination antiretroviral therapy (cART). It is not known whether the rate of CD4 cell decline prior to therapy is related to prognosis and should, therefore, influence the decision on when to initiate cART. METHODS AND FINDINGS: We carried out survival analyses of patients from the 23 cohorts of the CASCADE (Concerted Action on SeroConversion to AIDS and Death in Euro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1000239

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Babiker, A More by this author
Dorrucci, M More by this author
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Funding agency for:
Wolbers, M
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
7
Issue:
2
Pages:
Article: e1000239
Publication date:
2010-02-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:f58e2377-bd20-4793-bec9-d7a915c6b96b
Source identifiers:
113071
Local pid:
pubs:113071

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