Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer.

Journal article

PURPOSE: Angiogenesis and vascular endothelial growth factor (VEGF) expression are associated with a poor outcome in bladder cancer. To understand more about the mechanisms, we studied the role of delta-like 4 (DLL4), an endothelial-specific ligand of the Notch signaling pathway, in bladder cancer angiogenesis. EXPERIMENTAL DESIGN: The expression of DLL4, CD34, and VEGF were studied in a cohort of 60 bladder tumors and 10 normal samples using quantitative PCR. In situ hybridization was used ...

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Authors: Patel, N; Dobbie, MS; Rochester, M; Steers, G; Poulsom, R

• Publication status: Published
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
• Volume: 12
• Issue: 16
• Pages: 4836-4844
• Publication date: 2006-08-01
• DOI: 10.1158/1078-0432.ccr-06-0285
• EISSN: 1557-3265
• ISSN: 1078-0432
• Language: English
• Keywords: Actins; Neovascularization, Pathologic; Middle Aged; Prognosis; Cohort Studies; Humans; Urinary Bladder Neoplasms; Carcinoma, Transitional Cell; Antigens, CD34; Vascular Endothelial Growth Factor A; Female; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Up-Regulation; Aged; Aged, 80 and over; Polymerase Chain Reaction; Adult; Male