Journal article
A multimodal instrument for real-time in situ study of ultrasound and cavitation mediated drug delivery
- Abstract:
- The development of a multimodal instrument capable of real-time in situ measurements of cavitation activity and effect in tissue mimicking phantoms during ultrasound and cavitation mediated drug delivery experiments is described here. The instrument features an acoustic arm that can expose phantoms to high-intensity focused-ultrasound while measuring cavitation activity and an optical arm that monitors cavitation effect using confocal microscopy. This combination of modalities allows real-time in situ characterisation of drug delivery in tissue and tissue mimicking phantoms during ultrasound and cavitation mediated drug delivery experiments. A representative result, obtained with a tissue mimicking phantom and acoustically activated droplets, is presented here as a demonstration of the instrument’s capabilities and potential applications.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 22.9MB, Terms of use)
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- Publisher copy:
- 10.1063/1.4978811
Authors
+ RCUK Digital Economy Programme
More from this funder
- Funding agency for:
- Bian, S
- Grant:
- Centre for Doctoral Training in Healthcare Innovations EP/G036861/1
+ Royal Commission for the Exhibition of 1851
More from this funder
- Funding agency for:
- Bian, S
- Grant:
- Centre for Doctoral Training in Healthcare Innovations EP/G036861/1
- Publisher:
- AIP Publishing
- Journal:
- Review of Scientific Instruments More from this journal
- Volume:
- 88
- Issue:
- 3
- Pages:
- 034302
- Publication date:
- 2017-03-24
- Acceptance date:
- 2017-03-07
- DOI:
- EISSN:
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1089-7623
- ISSN:
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0034-6748
- Language:
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English
- Keywords:
- Pubs id:
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pubs:687938
- UUID:
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uuid:f57ff4b6-a3c1-4df4-9c25-e9a83537ed9d
- Local pid:
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pubs:687938
- Source identifiers:
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687938
- Deposit date:
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2017-04-06
Terms of use
- Copyright holder:
- Bian et al
- Copyright date:
- 2017
- Notes:
- © 2017 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license.
- Licence:
- CC Attribution (CC BY)
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