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Journal article

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Abstract:
Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology.

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Publisher copy:
10.2337/db11-0415

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Journal:
Diabetes
Volume:
60
Issue:
10
Pages:
2624-2634
Publication date:
2011-10-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:f57a283d-d6e8-45f0-b8c6-45de66096a85
Source identifiers:
172113
Local pid:
pubs:172113

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