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Modelling intracellular H(+) ion diffusion.

Abstract:

Intracellular pH, an important modulator of cell function, is regulated by plasmalemmal proteins that transport H(+), or its equivalent, into or out of the cell. The pH(i) is also stabilised by high-capacity, intrinsic buffering on cytoplasmic proteins, oligopeptides and other solutes, and by the extrinsic CO(2)/HCO(3)(-) (carbonic) buffer. As mobility of these buffers is lower than for the H(+) ion, they restrict proton diffusion. In this paper we use computational approaches, based on the f...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Progress in biophysics and molecular biology More from this journal
Volume:
83
Issue:
2
Pages:
69-100
Publication date:
2003-10-01
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
Language:
English
Keywords:
Pubs id:
pubs:106234
UUID:
uuid:f573415f-05ac-46e8-8fba-e10d8a538f97
Local pid:
pubs:106234
Source identifiers:
106234
Deposit date:
2013-11-17

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