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Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.

Abstract:

Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IgFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 A resolution structure of a three-domain fragment of human filamin A (IgFLNa19-21). The structure reveals an unexpected domain arrangement, with IgFLNa20 partially unfolded bringing IgFLNa21 into close proximity to IgFLNa19. Notably the N-terminu...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601827

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Journal:
EMBO journal More from this journal
Volume:
26
Issue:
17
Pages:
3993-4004
Publication date:
2007-09-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
pubs:246480
UUID:
uuid:f571fcdb-f10a-4db3-8d9c-bdbd4bb9a7e9
Local pid:
pubs:246480
Source identifiers:
246480
Deposit date:
2013-11-16

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