Journal article
The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
- Abstract:
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As a first host barrier, the skin is constantly exposed to environmental insults that perturb its integrity. Tight regulation of skin homeostasis is largely controlled by the aryl hydrocarbon receptor (AhR). Here, we demonstrate that Henna and its major pigment, the naphthoquinone Lawsone activate AhR, both in vitro and in vivo. In human keratinocytes and epidermis equivalents, Lawsone exposure enhances the production of late epidermal proteins, impacts keratinocyte differentiation and prolif...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 1.2MB)
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(Version of record, pdf, 2.8MB)
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- Publisher copy:
- 10.1038/s41598-019-47350-x
Authors
Bibliographic Details
- Publisher:
- Nature
- Journal:
- Scientific Reports More from this journal
- Volume:
- 9
- Article number:
- 10878
- Publication date:
- 2019-07-26
- Acceptance date:
- 2019-07-15
- DOI:
- EISSN:
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2045-2322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1032920
- UUID:
-
uuid:f565cb71-63f0-47e1-8d87-134484f69933
- Local pid:
- pubs:1032920
- Source identifiers:
-
1032920
- Deposit date:
- 2019-07-26
Terms of use
- Copyright holder:
- Lozza et al
- Copyright date:
- 2019
- Rights statement:
- ©2019 Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Notes:
- A correction to this article is available at: 10.1038/s41598-020-65510-2
- Licence:
- CC Attribution (CC BY)
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