Journal article

Inhibition of protein crystallization by evolutionary negative design.

Abstract:: Why are proteins so hard to crystallize? We propose an 'evolutionary negative design' principle to explain this difficulty. Proteins have evolved to avoid crystallization because crystallization compromises the viability of the cell. Evolutionary negative design is supported by much evidence in the literature, including the effect of mutations on the crystallizability of a protein, the correlations found in the properties of crystal contacts in bioinformatics databases, and the positive use of protein crystallization by bacteria and viruses.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Doye, J., Louis, A., & Vendruscolo, M. (2004). Inhibition of protein crystallization by evolutionary negative design. Physical Biology, 1(1-2), P9–13.

MLA Style

Doye, J., et al. “Inhibition of Protein Crystallization by Evolutionary Negative Design.” Physical Biology, vol. 1, no. 1-2, IOP Publishing, 2004, pp. P9–13.

Chicago Style

Doye, J, A Louis, and M Vendruscolo. 2004. “Inhibition of Protein Crystallization by Evolutionary Negative Design.” Physical Biology 1 (1-2): P9–13.
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Files:: 0402033v1.pdf

(Preview, Accepted manuscript, pdf, 112.6KB, Terms of use)

Publisher copy:: 10.1088/1478-3967/1/1/p02

Authors

+ Doye, J More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Physical & Theoretical Chem
Role:: Author

+ Louis, A More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Physics
Sub department:: Theoretical Physics
Role:: Author

+ Vendruscolo, M More by this author

Role:: Author

+ Royal Society More from this funder

Publisher:: IOP Publishing
Journal:: Physical biology More from this journal
Volume:: 1
Issue:: 1-2
Pages:: P9-13
Publication date:: 2004-06-01
DOI:: 10.1088/1478-3967/1/1/p02
EISSN:: 1478-3975
ISSN:: 1478-3967

Language:: English
Keywords:: Crystallization

Biophysics

Proteins

Mutation

Biophysical Phenomena

Evolution, Molecular
Pubs id:: pubs:39605
UUID:: uuid:f56300a3-6b58-477e-ac33-736f186ed779
Local pid:: pubs:39605
Source identifiers:: 39605
Deposit date:: 2013-03-20

Terms of use

Copyright holder:: IOP Publishing Ltd
Copyright date:: 2004
Notes:: Copyright 2004 IOP Publishing Ltd. All rights reserved. Jonathan P K Doye et al. 2004 Physical Biology v.1 (P9) DOI: 10.1088/1478-3967/1/1/P02

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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