Epistasis in sporadic Alzheimer's disease.

Journal article

The traditional approach in case-control association studies, to evaluate candidate genes individually, either single markers or haplotypes, has had limited success. The multifactorial nature of complex diseases suggests the alternative of examining gene-gene interactions (epistasis) within biological networks. We have used synergy factor analysis to assess over 100 claims of epistasis in sporadic Alzheimer's disease (AD), in networks involving, e.g. cholesterol, beta-amyloid, inflammation an...

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Authors: Combarros, O; Cortina-Borja, M; Smith, A; Lehmann, D

• Publication status: Published
• Journal: Neurobiology of aging
• Volume: 30
• Issue: 9
• Pages: 1333-1349
• Publication date: 2009-09-01
• DOI: 10.1016/j.neurobiolaging.2007.11.027
• EISSN: 1558-1497
• ISSN: 0197-4580
• Language: English
• Keywords: Humans; Epistasis, Genetic; Aspartic Acid Endopeptidases; Interleukin-6; Cholesterol; Encephalitis; Amyloid beta-Peptides; Oxidative Stress; Aged; Apolipoprotein E4; Amyloid Precursor Protein Secretases; Alzheimer Disease