Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain.

Journal article

Hypoxia-inducible factor (HIF) mediates a large number of transcriptional responses to hypoxia and has an important role in processes that include angiogenesis and erythropoiesis. The HIF DNA binding complex consists of 2 basic-helix-loop-helix PAS proteins designated alpha and beta subunits. Regulation occurs principally through the alpha subunits, which are stabilized and activated in hypoxia. Although substantial evidence implicates reactive oxygen species (ROS) in the regulatory process, ...

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Authors: Vaux, E; Metzen, E; Yeates, K; Ratcliffe, P

• Publication status: Published
• Journal: Blood
• Volume: 98
• Issue: 2
• Pages: 296-302
• Publication date: 2001-07-01
• DOI: 10.1182/blood.v98.2.296
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Cell Hypoxia; Humans; Monosaccharide Transport Proteins; DNA, Mitochondrial; Animals; Polymerase Chain Reaction; Cricetulus; CHO Cells; Tumor Cells, Cultured; Cell Line; Cricetinae; Rotenone; Nuclear Proteins; Glucose Transporter Type 1; Electron Transport; Oxygen Consumption; Osteosarcoma; Hypoxia-Inducible Factor 1; Transcription Factors; Lung Neoplasms; Mitochondria; Gene Expression Regulation; DNA-Binding Proteins; Ethidium; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit