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Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain.

Abstract:

Hypoxia-inducible factor (HIF) mediates a large number of transcriptional responses to hypoxia and has an important role in processes that include angiogenesis and erythropoiesis. The HIF DNA binding complex consists of 2 basic-helix-loop-helix PAS proteins designated alpha and beta subunits. Regulation occurs principally through the alpha subunits, which are stabilized and activated in hypoxia. Although substantial evidence implicates reactive oxygen species (ROS) in the regulatory process, ...

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Publication status:
Published

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Publisher copy:
10.1182/blood.v98.2.296

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Blood
Volume:
98
Issue:
2
Pages:
296-302
Publication date:
2001-07-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
3366

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