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Mepolizumab and exacerbations of refractory eosinophilic asthma.

Abstract:

BACKGROUND: Exacerbations of asthma are associated with substantial morbidity and mortality and with considerable use of health care resources. Preventing exacerbations remains an important goal of therapy. There is evidence that eosinophilic inflammation of the airway is associated with the risk of exacerbations. METHODS: We conducted a randomized, double-blind, placebo-controlled, parallel-group study of 61 subjects who had refractory eosinophilic asthma and a history of recurrent severe ex...

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Publisher copy:
10.1056/nejmoa0808991

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Journal:
New England journal of medicine More from this journal
Volume:
360
Issue:
10
Pages:
973-984
Publication date:
2009-03-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793

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